PQEI Practice Test

1Multiple ChoiceSelect all that apply

A 55-year-old patient (weight 70 kg) with a creatinine clearance of 30 mL/min is to be started on vancomycin. Which TWO of the following pharmacokinetic adjustments are most appropriate when designing the dosing regimen?

A.Increase the loading dose proportionally to the degree of renal impairment
B.Extend the dosing interval because the elimination half-life is prolonged
C.Reduce the maintenance dose because clearance is reduced
D.Discontinue vancomycin because it is contraindicated in renal impairment
E.Use a larger initial (loading) dose to rapidly achieve therapeutic concentrations when volume of distribution is unchanged
F.Administer the drug by continuous infusion regardless of renal function

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