PQSPE Practice Test

1Multiple ChoiceSelect all that apply

A 58-year-old patient with type 2 diabetes mellitus is initiated on metformin. Which of the following statements accurately describe the mechanism and clinical use of metformin? (Choose two.)

A.It primarily acts by inhibiting hepatic gluconeogenesis.
B.It causes significant weight gain and is therefore avoided in overweight patients.
C.It increases peripheral insulin sensitivity by activating AMP-activated protein kinase (AMPK).
D.It is contraindicated in patients with an estimated glomerular filtration rate (eGFR) greater than 60 mL/min/1.73 m??.
E.It is contraindicated in patients with a history of lactic acidosis.

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