2PHEN Practice Test

1Multiple ChoiceSelect all that apply

A 58-year-old patient is being treated for chronic heart failure with digoxin. Which of the following statements about digoxin pharmacokinetics and pharmacodynamics are correct? (Choose two.)

A.Digoxin has a large volume of distribution, primarily binding to skeletal muscle Na+/K+-ATPase
B.The therapeutic index of digoxin is wide, making toxicity uncommon with standard doses
C.Digoxin is eliminated mainly by hepatic microsomal CYP3A4 metabolism
D.Quinidine can increase serum digoxin levels by reducing its renal and non-renal clearance
E.Digoxin exerts positive inotropy by inhibiting cardiac Na+/K+-ATPase, leading to increased intracellular Ca2+

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